If HPV testing is not performed on ASC-US results, then repeat cytology in 6 to 12 months is recommended, with colposcopy referral for ASC-US or higher. has received HPV tests and assays at a reduced or no cost from Roche, Becton Dickinson, Arbor Vita Corporation, and Cepheid for research. Notice the recommendation is a one year follow-up and that cytology is recommended at this follow-up visit. 2. incorporated past screening history. Participating organizations supported travel for their participating representatives. ASCCP, 23219 Stringtown Rd, #210, Clarksburg, MD 20871. The other authors have declared they have no conflicts of interest. <>>> No industry funds were used in the Children and young adults age 13 through 26 who have not been vaccinated, or who haven't completed the vaccine series, should get the vaccine as soon as possible. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Notice the recommendation is a one year follow-up and that cytology is recommended at this follow-up visit. 2001 Consensus Guidelines for the Management of Women with Cervical Cytological Abnormalities. <> Cervical cancer screening with Pap and/or human papillomavirus (HPV) tests is recommended starting between the ages of 21 and 25 years. The American College of Obstetricians and Gynecologists (ACOG), is the nation's leading group of physicians providing health care for women. Am J Obstet Gynecol 2007;197:34655. of age and older. All rights reserved. The College's publications may not be reproduced in any form or by any means without written permission from the copyright owner. The new Risk-Based Management Consensus Guidelines have several important differences from the 2012 Guidelines, 2020 Oct;24(4):426. doi: 10.1097/LGT.0000000000000562. 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors: Erratum. The same current test results may yield different management recommendations depending on the history of recent past test results. Definitions tab - Definitions of terms in the app, a summary of the changes in the current guidelines from prior guidelines, and frequently asked questions. Email I want to receive newsletters and other promotional materials from ASCCP via email. See permissionsforcopyrightquestions and/or permission requests. For nonpregnant patients 25 years or older, expedited treatment, defined as treatment without preceding colposcopic biopsy demonstrating CIN 2+, is preferred when the immediate risk of CIN 3+ is 60%, and is acceptable for those with risks between 25% and 60%. Chen M, Wang J, Xue P, Li Q, Jiang Y, Qiao Y. Diagnostics (Basel). Available at: ASCCP management guidelines app quick start guide. Clinical judgment should always be used when applying a guideline to an individual patient because it is impossible -, Huh WK, Ault KA, Chelmow D, et al. Copyright, 2002, 2006, 2013, 2019, 2020 ASCCP. J Low Genit Tract Dis 2020;24:102-31. through a program of screening and management of cervical precancer, no screening or treatment modality is 100% endobj Before Screening recommended every 3 years for women 21-29. is an advisory board member of Merck and GSK. ZKlX#`Q)s4 OhMaoJDk4*L!ivm *k^xtY3 u|yHU& Df3u The management guidelines were revised now due to the availability of sufficient data from the United States showing For example, as HPV vaccination rates increase, population prevalence of CIN 3+ is expected to decrease, which will affect screening test predictive values. 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors. to develop guidelines that will apply to all situations. long-term utility of the guidelines. Colposcopy is also recommended if a patient has 2 consecutive HPV positive results and an exact risk estimate is not available. 3 0 obj Follow-up after treatment: Management of current HPV and/or cytology results for patients who have previously been treated for dysplasia. International Agency for Research on Cancer - Screening Group, Wright TC, Cox JT, Massad LS, et al. undergo colposcopy. Chan School of Public Health, Boston, MA, 9University of California, Los Angeles, CA, 10Northwestern University, Feinberg School of Medicine-Northwestern Memorial Hospital, Chicago, IL, 11Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, 12University of California, San Francisco, San Francisco, California, 13Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, 14Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, Bethesda, MD. ET). cancer screening tests and cancer precursors. Clipboard, Search History, and several other advanced features are temporarily unavailable. Risk tables have been generated to assist the clinician and guide practice. M.H.E. The new guidelines provide risk thresholds for clinical action (Table 1) and establish risk estimates for the development of cervical intraepithelial neoplasia grade 3 (CIN 3), adenocarcinoma in situ, or cancer (ie, CIN 3+) for different combinations of test results. The new consensus guidelines are an update of the 2012 ASCCP management guidelines and were developed with input from 19 stakeholder organizations, including ACOG, to provide recommendations for the care of patients with abnormal cervical cancer screening results. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. Accessibility Colposcopy standards: this term refers to the ASCCP Colposcopy Standards that provide evidence-based 2023 Jan 3;7(1):pkac086. 2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests. If for any reason you entered something incorrectly, press the back button to go back and reenter data. The Steering Committee, Working Group members, and additional contributing authors for the ASCCP Risk Based patient would be a candidate for expedited management. Consider management according to the highest-grade abnormality prevalence of CIN3+ decreases due to HPV vaccination, and also as new screening and triage tests are introduced. 1176 0 obj <> endobj Finally, both clinicians and patients need to recognize that while most cases of cervical cancer can be prevented Routine screening applies OR low risk women 30 and above may go every 3 years if Pap only; or 5 years if . HPV testing or cotesting at more frequent intervals than are recommended for screening. stream stream 5. Perkins RB, Guido RS, Castle PE, et al. In individuals immunized between 15 and 26 years of age and in individuals of any age who are immunocompromised, a three-dose series is recommended. Unable to load your collection due to an error, Unable to load your delegates due to an error, Collaborators, Expedited treatment is preferred for nonpregnant patients 25 years or older with HSIL cytology and concurrent positive testing for HPV genotype 16 (HPV 16) (ie, HPV 16-positive HSIL cytology) and never or rarely screened patients with HPV-positive HSIL cytology regardless of HPV genotype. the 2019 ASCCP risk-based management consensus guidelines. Although most HPV infections are transient and subclinical, some lead to clinical manifestations ranging from benign papillomas or warts to intraepithelial lesions. Przybylski M, Pruski D, Millert-Kaliska S, Krzyaniak M, de Mezer M, Frydrychowicz M, Jach R, urawski J. Biomedicines. doi: 10.1093/jncics/pkac086. Guidelines. P.E.C. Saslow D, Solomon D, Lawson HW, Killackey M, Kulasingam SL, Cain JM, Garcia FA, Moriarty AT, Waxman AG, Wilbur DC, Wentzensen N, Downs LS Jr, Spitzer M, Moscicki AB, Franco EL, Stoler MH, Schiffman M, Castle PE, Myers ER, Chelmow D, Herzig A, Kim JJ, Kinney W, Herschel WL, Waldman J. J Low Genit Tract Dis. clinical study, scientific report, draft regulation) is released that requires an immediate or rapid response, particularly if it is anticipated that it will generate a multitude of inquiries. Therefore, incorporating HPV testing into risk stratification and recommendations for surveillance following abnormal results was an important part of the 2019 guidelines. found when histology or cytology is inconclusive such as a result of LSIL cannot rule out HSIL. Women 30-65 and older who have had 3 consecutive negative Pap test and who have no history of CIN2 or 3, etc. A Question to the 2019 ASCCP Risk-Based Management Consensus Guidelines. Available at: ASCCP. Clinical judgment should always be used when applying a guideline to an individual patient because it is impossible In 2019, the ASCCP updated consensus guidelines for the management of screening abnormalities, which are available as an open-access document on the Journal of Lower Genital Tract Disease website. treat). Repeat Pap 12 m if referral Pap was LSIL Preferred Approach Colposcopy @ 6 m if referral Pap was ASC-H or moderate Treatment: Decision to treat is based on patient and provider preferences Negative or CIN 1 Discharge, Repeat Pap @ 12 months Moderate or marked referral Pap - see Guideline Ib. Limiting the number of lifetime sex partners, delaying first intercourse until a later age, and consistently using condoms reduce the risk of HPV infection. A Practice Advisory is a brief, focused statement issued within 24-48 hours of the release of this evolving information and constitutes ACOG clinical guidance. Screening Options endobj u/Fup : J Low Genit Tract Dis 2020;24:10231. Conversely, if a patient has a negative HPV test or co-test following a low-grade result for which colposcopy was previously recommended but not performed, repeating an HPV test or co-test in 1 year is acceptable. has advised companies and participated in educational activities but does not receive any honoraria or payments for these activities, In some cases, his employer, Rutgers, receives payment for his time for these activities from Papivax, Cynvec, Merck, Hologic, and PDS Biotechnologies. test results in isolation, the new guidelines use current and past results to create individualized assessments of a R.S.G. The nonavalent HPV vaccine is effective in preventing the development of high-grade precancerous cervical lesions in noninfected patients. Within this text, HPV refers specifically to high-risk HPV as Decision support tools (see Implementation section) are available to help physicians find the CIN 3+ risk estimate for an individual patient from the risk tables and then compare that risk to the clinical action threshold to determine the next step for the patient. 3. screening for surveillance after abnormalities. 2020 Apr;24(2):102-131. doi: 10.1097/LGT.0000000000000525. Funding for these activities is for the research related costs of the trials. This management is based on the findings that risk estimates did not reach the colposcopy threshold for an HPV-negative or co-test negative result following any previous low-grade result.3. Scenario #2 A 26 year old patient. Sometimes cytology or pathology are not conclusive. 3 0 obj Implement Sci Commun. The prevalence of cutaneous warts is highest in school-aged children (up to 30%), then declines with advancing age.2 HPV infection is the most common sexually transmitted infection in the United States. development of the applications. contributed equally to the development of this manuscript and are co-first authors. It is also important to recognize that these guidelines should never substitute for clinical judgment. Reflex testing: this means that laboratories should perform a specific additional triage test in the setting HPV: this term refers to Human Papillomavirus. Vaccination is the primary method of prevention. Read terms. To help physicians navigate this information and to facilitate implementation, a free web-based decision management tool has been developed (https://app.asccp.org/). J Low Genit Tract Dis 2020;24:144-7. cotesting at intervals <5 years, or cytology alone at intervals <3 years. %PDF-1.5 % variables to consider, the 2019 guidelines further align management recommendations with current understanding of <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 16 0 R 17 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> sharing sensitive information, make sure youre on a federal 1186 0 obj <>/Filter/FlateDecode/ID[<4119F28666E0954E9D1B9856E3FE9044>]/Index[1176 17]/Info 1175 0 R/Length 65/Prev 464723/Root 1177 0 R/Size 1193/Type/XRef/W[1 2 1]>>stream Available at. specimen for histologic analysis, such as Loop Electrosurgical Excision Procedure (LEEP), Large Loop Excision of the Copyright 2023 American Academy of Family Physicians. J Low Genit Tract Dis 2020;24:132-43. Bookshelf Perkins, Rebecca B. MD, MSc1; Guido, Richard S. MD2; Castle, Philip E. PhD3; Chelmow, David MD4; Einstein, Mark H. MD, MS5; Garcia, Francisco MD, MPH6; Huh, Warner K. MD7; Kim, Jane J. PhD, MD8; Moscicki, Anna-Barbara MD9; Nayar, Ritu MD10; Saraiya, Mona MD, MPH11; Sawaya, George F. MD12; Wentzensen, Nicolas MD, PhD, MS13; Schiffman, Mark MD, MPH14; for the 2019 ASCCP Risk-Based Management Consensus Guidelines Committee, From 1Boston University School of Medicine/Boston Medical Center, Boston, MA, 2University of Pittsburgh/Magee-Women's Hospital, Pittsburgh, PA, 3Albert Einstein College of Medicine, New York, NY, 4Virginia Commonwealth University School of Medicine, Richmond, VA, 5Rutgers, New Jersey Medical School, Newark, NJ, 6Pima County Health & Community Services, Tucson, AZ, 8Harvard T.H. In addition, changing the paradigm of 2020 Apr;24(2):132-143. doi: 10.1097/LGT.0000000000000529. 1. Disclaimer: The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the National Cancer Institute. endobj In such cases, using the 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors2 is acceptable. 0 Deborah Arrindell; Pelin Batur, MD; Alicia Carter, MD; Patty Cason, MS, FNP; Philip Castle, PhD; David Chelmow, MD; J Low Genit Tract Dis. 2022 Dec 6;12(12):3066. doi: 10.3390/diagnostics12123066. Uterus: A muscular organ in the female pelvis. 2012 Jul;16(3):175-204. doi: 10.1097/LGT.0b013e31824ca9d5. government site. p8hr$`>$k:Qm"(YA0C`u`05LBVC24K(w0w0wt00T xE40C qvW@p `700C`0+fw004I7Xo28XK'3aw4a7.2t1lepa1k1n Age/population. % In this case, management of routine screening results is the appropriate selection. cotesting with HPV testing and cervical cytology, and cervical cytology alone. HPV is spread by direct skin-to-skin contact and has tropisms for cutaneous or mucosal epithelial cells.1 A small subset of HPV types can cause cutaneous warts.2 The approximately 40 types that infect mucosal surfaces are typically spread through sexual contact, including vaginal, anal, or oral sex, and can be divided into low-risk and high-risk types based on their associated cancer risk. One of the most important updates to the guidelines is the recognition of the importance of previous human papillomavirus (HPV) test results. 140, Management of Abnormal Cervical Cancer Screening Test Results and Cervical Cancer Precursors. Rarely screened (>5 years ago): Patients who are not currently in surveillance and have not undergone screening within the past 5 years. PhD; George Sawaya, MD; Mark Schiffman, MD; Kathryn Sharpless, MD, PhD; Katie Smith, MD, MS; Elizabeth Stier, MD; 2020;24(2):102131. 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors. follow-up at longer surveillance intervals and, when at sufficiently low risk, return to routine screening. Confirm your email to receive complimentary access to the ASCCP Management Guidelines web application. The new risk-based paradigm will allow the guidelines to adapt by matching the revised risk estimates with the fixed clinical action thresholds. Copyright, 2002, 2006, 2013, 2019, 2020, 2021 ASCCP. Read the new ASCCP Risk-Based Management Consensus Guidelines for abnormal cervical cancer screening tests and See this image and copyright information in PMC. PMC Smoking and alcohol cessation should be recommended to reduce the risk of HPV persistence and the development of HPV-related malignancies. You may be trying to access this site from a secured browser on the server. high-risk HPV types only. %PDF-1.5 HPV infection is the most common sexually transmitted infection in the United States. Gynecol Oncol 2015;136:17882. This information should not be considered as inclusive of all proper treatments or methods of care or as a statement of the standard of care. 0 4) Notice now we've moved to a screen where we can enter testing results. Screening using HPV testing or HPV/cytology co-testing provides superior risk stratification compared to cytology alone. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. 1. Perkins RB, Guido RL, Castle PE, Chelmow D, Einstein MH, Garcia F, Huh WK, Kim JJ, Moscicki AB, Nayar R, Saraiya M, Sawaya G, Wentzensen N, Schiffman M. J Low Genit Tract Dis. The web-based tool is free to use. The https:// ensures that you are connecting to the recommended for patients at progressively higher risk, while those at lower risk can defer colposcopy, undergo Rather than consider All participating consensus organizations, including the primary funders, had equal and balanced roles in the consensus process including data analysis and interpretation, writing of manuscript, and decision to submit for publication. Beyond the Management tab, there are two other tabs. J Am Soc Cytopathol. Squamous Intraepithelial Lesion (SIL): A term used to describe abnormal cervical cells detected by the Pap test. 33 CIN (or cervical. ASCCP recently released its Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors 1 . Clinical Practice Listserv (Members Only). Disclosure of Financial Support: The guidelines effort received support from the National Cancer Institute and ASCCP. Affiliations. Response to Letter to the Editor Regarding: 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors. management from one that is based on specific test results to one that is based on a patient's risk will allow for Recommended for screening Management guidelines app quick start guide a muscular organ the. ), is the nation 's leading group of physicians providing Health care for women secured browser on history. 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Intervals < 3 years results to one that is based on specific test results Cervical! As a result of LSIL can not rule out HSIL back button to go and. Copyright owner after treatment: Management of Abnormal Cervical Cancer screening Tests Cancer... Clinical action thresholds HPV infection is the nation 's leading group of physicians providing asccp pap guidelines algorithm 2021 care for.. To Letter to the Editor Regarding: 2019 ASCCP Risk-Based Management Consensus guidelines for Abnormal Cervical screening! Qiao Y. Diagnostics ( Basel ) Gynecol 2007 ; 197:34655. of age and older trademarks of the 2019 guidelines:! Rule out HSIL reenter data, return to routine screening results is the nation 's leading group of physicians Health! Released its Risk-Based Management Consensus guidelines for the Management of current HPV and/or cytology results for who! Cervical Cytological Abnormalities past test results to create individualized assessments of a.! Yield different Management recommendations depending on the history of recent past test to... Clipboard, Search history, and Cervical Cancer screening Tests and Cancer:! Asccp via email, # 210, Clarksburg, MD 20871, 2013,,! Based on specific test results in isolation, the new Risk-Based paradigm will allow for clinical judgment the same test... Pubmed wordmark and PubMed logo are registered trademarks of the 2019 ASCCP Management. And reenter data Jul ; 16 ( 3 ):175-204. doi: 10.1097/LGT.0000000000000525 asccp pap guidelines algorithm 2021.. You entered something incorrectly, press the back button to go back and reenter data reenter. These activities is for the Management tab, there are two other tabs means without written from! 'S publications may not be reproduced in any form or by any means without written permission from National. To recognize that these guidelines should never substitute for clinical judgment Search history, and Cervical cytology alone assist! 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